3 edition of Biometals and ligands for anticancer drug design found in the catalog.
Biometals and ligands for anticancer drug design
E. A. Parfenov
Includes bibliographical references and indexes.
|Statement||E.A. Parfenov and G.E. Zaikov.|
|Contributions||Zaikov, Gennadiĭ Efremovich.|
|The Physical Object|
|Pagination||2 v. :|
A dance of mirrors: book 3 of shadowdance; Daniel's pet; Biometals & ligands for anticancer drug design: superoxide dimutase models in combined tumor therapy; Das getriebebuch; Blackbeard: the hunt for the world's most notorious pirate. Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking ing with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules .
Book Description. Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and information is presented in an up-to . The effectiveness of anticancer drug treatment can be achieved only when the administered drug is of proper dosage and display maximal activity in the cancer cells. Thus, the nanomaterials used for targeting tumor cells should have the capability of increasing local concentration of the drugs in and around tumor cells, thereby reducing the.
In conclusion, ruthenium compounds have shown highly promising anticancer activity in cells, animals and humans. To date, two compounds are being evaluated in phase II clinical trials. However, a major limitation in ruthenium drug discovery is their unknown mode of action. This leads to three possible strategies for future ruthenium drug design. Elements of Propulsion: Gas Turbines and Rockets, Second Edition (Aiaa Education) Surviving Supply Chain Integration: Strategies for Small Manufacturers Building Construction Technology (industrial and civil buildings professional)(Chinese Edition) Innovation in Global Industries: U.S. Firms Competing in a New World (Collected Studies) (Variorum Collected Studies) Principles .
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Get this from a library. Biometals and ligands for anticancer drug design: molecular mechanisms of superoxide dismutase models antitumor effects.
[E A Parfenov; G E Zaikov]. Biometals and Ligands for Anticancer Drug Design. Author: E. Parfenov Release date: Publisher: Nova Science Pub Incorporated Number of Pages: pages Ether Lipids Chemistry and Biology.
Author: Fred Snyder Release date: Publisher: Elsevier. Author(s): Parfenov,E A; Zaikov,G E(Gennadiĭ Efremovich), Title(s): Biometals and ligands for anticancer drug design: molecular mechanisms of superoxide dismutase models antitumor effects/ E.A. Parfenov and G.E. Zaikov. The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design.
Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures anReviews: 1. Keywords:G-quadruplexes, telomeric DNA, telomeres, targets, anticancer drug, metal complexes, ligand, stabilization.
Abstract: Guanine-rich DNA sequences can form planar four-stranded structures via Hoogsteen hydrogen bonds. These sequences in telomeric DNA and some oncogenes have been identified as targets for novel anticancer drugs.
Sandeep Waghulde, MK Kale and VR Patil. In silico docking and drug design of herbal ligands for anticancer property. ; 7(6S): DOI: / Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often been exploited in areas such as catalysis and materials chemistry.
They also offer opportunities for the design of new drugs with novel mechanisms of action. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy.
Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Explore the latest full-text research PDFs, articles, conference papers, preprints and more on IN SILICO DRUG DESIGN. Find methods information, sources, references or.
Home / Publication: Anti-Cancer Drug Design Anti-Cancer Drug Design. ISSN (Print); ISSN (Online) Ceased publication in Publisher: Cognizant Communication Corporation.
27 Issues are available Fast Track; Supplementary Data; Issues  Fast Track; Supplementary Data; Volume 16; Number 6, ; Number 4. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all.
drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.
Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and information is presented in an up-to.
In this book, you'll learn the value of a robot heartbeat and the purpose of the wavy lines in photocells. A Practical Guide Biometals and Ligands for Anticancer: Drug Design Molecular Mechanisms of Superoxide Dismutase Models Antitumor Effects. a series of chapters on present-day conditions Handbook of Plastics Joining: A Practical.
An important challenge in this field is the design of complexes that bind selectively to quadruplex over duplex DNA. Whereas the Ni(ii)-salphen complex 11 shows selectivity of > fold, the manganese porphyrin 12 (Figure 2a) which follows the same design criteria as mentioned previously, shows an exceptiofold selectivity for quadruplex over duplex DNA (IC.
G-quadruplex nucleic acid, which is formed by self-assembly of guanine-rich nucleic acid sequences, has recently been considered as an attractive target for anticancer drug design. The basic unit of a G-quadruplex is a G-quartet, a planar motif generated from four guanine residues pairing together through Hoogsteen like hydrogen bonds.
This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design.
A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given.2/5(1). Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and information is presented in an up-to Reviews: 4.
SRC as a target for anti-cancer Cancer Drug Des Article. May ; The data unequivocally suggest that all three ligands bind in. Tuning of Redox Properties for the Design of Ruthenium Anticancer Drugs: Part 2.
Syntheses, Crystal Structures, and Electrochemistry of Potentially Antitumor [RuIII/IICl6-n(Azole)n]z (n = 3, 4, 6) Complexes†.
Inorganic Chemistry44 (19), DOI: /ic. The ligands of platinum anticancer complexes determine a multitude of factors including reactivity, distribution, tumour selectivity and penetration, cellular accumulation, mode of cytotoxicity, type of pharmaceutical formulation required, and route of drug administration.Biometals and ligands for anticancer drug design: molecular mechanisms of superoxide dismutase models antitumor effects / by: Parfenov, E.
A. Published: () Ligand design in medicinal inorganic chemistry / Published: ().The structural diversity of metal scaffolds makes them a viable alternative to traditional organic scaffolds for drug design. Combinatorial chemistry and multicomponent reactions, coupled with high-throughput screening, are useful techniques in drug discovery, but they are rarely used in metal-based drug design.
We report the optimization and validation of a new combinatorial.